An acute infection is associated with trauma to the skin such as a hangnail, ingrown nail, or nail-biting. The most common bacteria responsible is Staphylococcus aureus. Other bacteria that are less commonly involved are Streptococcus species and Pseudomonas species. Here's a pic for my first day on accutane 40mg which is one pill. I took it last night 3/1/17 with my dinner. Summary. Fungal nail infection is found among people who take Accutane, especially for people who are male, 10-19 old , have been taking the drug for 1 - 6 months, also take medication Dermatop, and have Asteatosis. LOL! I was just about to post this! Just today(3 weeks into Accutane) I noticed this happening. I'm using Aquaphor healing ointment(got this from my MD-but you can get it at the store), Antibiotic ointment for cuts, and Blistex-yes the same stuff I'm also putting on my lips. Acute paronychia most commonly results from nail biting, finger sucking, aggressive manicuring, a hang nail or penetrating trauma, with or without retained foreign body3. Along with its needed effects, isotretinoin (the active ingredient contained in Accutane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. A fungal nail infection could lead to more serious problems if you have diabetes or a weak immune system. Talk to your doctor about the best way to treat a nail infection if you have one of these. However, due to the sensitivity and fragility of the skin while on accutane this allows the skin to become damaged much easier just from stubbing your toe or from shoes not fitting properly (due creating compression with the incorrectly growing toe nail) and subsequently prone to infection etc. After 4 myths on Accutane I had to stop my treatment due to a staph infection. Accutane dries the skin and can dry nails causing them to be brittle.Nails can be slow growing. But it will take several months for the new healthy nail to grow out. Paronychia , infection of nail folds, usually with staph. Aureus occurs in ingrown , chewed or picked nails. With discontinuance of drug, nails eventually heal.